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Kwam e.e.a tegen op een Amerikaanse medische database, waar normaliter veel goed onderbouwde info op staat.
Potent antiviral effect of silver nanoparticles on SARS-CoV-2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486059/
"Several studies have reiterated the size dependent antiviral effect of AgNPs with particles around 10 nm diameter being most effective [1].
This has been attributed the higher stability of interaction to the viral protein achieved by 10 nm particles which is not capable by larger particles [11].
Consistent with this, we also observed anti-SARS-CoV-2 activity only with AgNPs of diameters ranging from 2 to 15 nm.
Our immunofluorescence study corroborated the above phenomenon, as we observed that PVP-AgNP10 completely inhibited SARS-CoV-2 but AgNP100 did not."
Polyvinylpyrrolidone-Capped Silver Nanoparticle
"AgNPs can be generated by several methods and can contain reducing agents and capping agents along with the metal particles [16].
Coated or capped AgNPs are found to be more advantageous than plain AgNPs as coating increases stability, decreases agglomeration and reduces cytotoxicity of AgNPs [17].
Among the coated AgNPs, PVP capped nanoparticles are widely studied for biological use.
It has been observed that PVP coating of AgNPs does not hinder their antiviral activity while other coating agents do [18].
PVP-AgNP10 has been demonstrated to possess excellent antiviral activity against enveloped viruses such as RSV and HIV [11,19].
This was the rationale to select PVP-AgNP10 for the study and we have demonstrated the robust antiviral effect of PVP-AgNP10 against SARS-CoV-2."
"Antiviral effect of AgNPs is also concentration dependent.
Most studies have observed the antiviral efficacy of AgNPs at concentrations ranging between 10 and 100 ppm [1].
However, 0.5 ppm cAg has been shown effective in inhibiting Influenza virus and is the least concentration that has been reported to show antiviral activity [20].
In the current study, we observed naked AgNPs to inhibit SARS-CoV-2 at concentrations ranging between 1 and 10 ppm and become cytotoxic to mammalian cells from 20 ppm and above."